90% of cases with orange discoloration of skin is caused by using Benzoyl Peroxide (BP) or other peroxides. If you are not using BP or other peroxides, please stop using The Spot Cream for a week to see if the orange discoloration subsides. If it does not subside, The Spot Cream may not be the cause. If it does subside, we recommend discussing alternatives (different formulas or treatments) with your assigned dermatologist.