Do I have to use sunscreen with my FaceRx medication? October 20, 2020 17:58 Updated Yes. Sunscreen is crucial when using all FaceRx treatments, as the medication could make your skin more sensitive to the sun. Related articles Can I undergo any facial procedures while using FaceRx treatments? How do I apply the treatment? Can I use The Spot Cream on my body? I am red, itchy, and experiencing side effects. What do I do? What is tretinoin?